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ATAC-Seq Peak Finding Analysis The following published ATAC-seq datasets were analyzed: untreated, BDG 1h, BDG 4h, and BDG 24h stimulated monocytes (GEO: GSE85246) ( Supplementary Table 2A )

FIGURE 1 2.1 Iron metabolism imbalance Iron, an essential trace element, primarily participates in metabolic processes in the forms of Fe 2+ and Fe 3+ (Lee and Roh, 2025)

Stickler syndrome: correlation between vitreoretinal phenotypes and linkage to COL 2A1

Changes in the redox state of cells by cystine/cysteine circuitry control the ROS levels, which modulates cellular signal transduction pathways involved in cell survival and resistance to chemotherapy

Fourier-transform infrared (FTIR) spectroscopy showed characteristic bands at 2558.3 cm 1 (S-H thiol stretch), 1724.2 cm 1 (C=O carboxylic acid stretch), and 1644.1 cm 1 (amide stretch)